Macrolides and analogues
Cayman Chemical 5Z-7-Oxozeaenol 1mg
A TAK1 inhibitor (IC50 = 8.1 nM in the presence of TAB1); selective for TAK1 over MEK1 and MEKK1 (IC50s = 411 and 268 nM, respectively), as well as ASK1 and IKKβ at 300 nM; inhibits NF-κB activity in a reporter assay using HEK293 cells expressing TAK1 and TAB1 (IC50 = 83 nM); reduces IL-1-induced increases in COX-2 levels in MEFs; sensitizes HeLa cells to TRAIL-induced apoptosis at 300 nM; induces necroptosis when used in combination with TNF and zVAD in primary mouse BMDMs at 100 nM; topical application prevents picryl chloride-induced increases in EAr thickness in mice
Cayman Chemical 5Z-7-Oxozeaenol 5mg
A TAK1 inhibitor (IC50 = 8.1 nM in the presence of TAB1); selective for TAK1 over MEK1 and MEKK1 (IC50s = 411 and 268 nM, respectively), as well as ASK1 and IKKβ at 300 nM; inhibits NF-κB activity in a reporter assay using HEK293 cells expressing TAK1 and TAB1 (IC50 = 83 nM); reduces IL-1-induced increases in COX-2 levels in MEFs; sensitizes HeLa cells to TRAIL-induced apoptosis at 300 nM; induces necroptosis when used in combination with TNF and zVAD in primary mouse BMDMs at 100 nM; topical application prevents picryl chloride-induced increases in EAr thickness in mice
Apexbio Technology LLC (5Z)-7-Oxozeaenol(Synonyms: (5Z)-7-Oxozeaenol, 7-Oxozeaenol, TAK1 inhibitor, MAPKKK inhibitor), 1mg, CAS: 253863-19-3.
(5Z)-7-Oxozeaenol (CAS 253863-19-3) is a naturally occurring resorcylic lactone obtained from fungal sources It functions as a selective inhibitor of transforming growth factor -activated kinase 1 (TAK-1) a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family In biochemical assays (5Z)-7-Oxozeaenol inhibits purified TAK-1 with an IC50 of approximately 8 1 nM exhibiting minimal activity against related MAPKKKs Cellular studies indicate irreversible blockade of IL-1-stimulated TAK-1 NF- B and JNK/p38 signaling pathways This molecule is useful in inflammation research as demonstrated by its suppression of IL-1-induced COX-2 production and attenuation of inflammatory responses in mouse models
Apexbio Technology LLC Epothilone B (EPO906, Patupilone)(Synonyms: Patupilone, EPO906, Epothilone B, (-)-Epothilone B, Epothilone B lactam), 5mg, CAS: 152044-54-7.
Epothilone B (EPO906 Patupilone CAS 152044-54-7) is a naturally occurring macrocyclic lactone initially isolated from the myxobacterium Sorangium cellulosum Sharing a mechanism of action similar to paclitaxel Epothilone B stabilizes microtubules thereby inhibiting cellular mitosis In vitro Epothilone B displays potent cytotoxic activity with an EC0 01 of approximately 1 8 nM Importantly Epothilone B effectively counters resistance mediated via P-glycoprotein which confers paclitaxel resistance and exhibits superior aqueous solubility compared to paclitaxel Research indicates Epothilone B treatment elevates intracellular free calcium and cytosolic cytochrome C in ovarian cancer SKOV-3 cells highlighting its utility as a research tool in cancer biology and chemotherapy resistance studies
Apexbio Technology LLC Zearalenone(Synonyms: F-2 toxin, Mycotoxin F2, Zearalenolactone, RAL, ZEA, Zenon), 5mg, CAS: 17924-92-4.
Zearalenone (CAS 17924-92-4) is a mycotoxin produced primarily by Fusarium fungi frequently contaminating feed and food products It exhibits estrogenic activity through interaction with estrogen receptors thus altering endocrine signaling pathways Although acutely low in toxicity zearalenone effectively modulates estrogen receptor-mediated responses influencing hormonal balance in livestock species such as pigs cattle and sheep In biomedical research zearalenone serves as a tool compound to study estrogen receptor-mediated mechanisms and endocrine disruption particularly in young animals within veterinary pharmacological contexts
Medchemexpress LLC 5Z-7-oxozeaenol | 253863-19-3 | MFCD12912700 | 99.6% | 362.37 g/mol | C19H22O7 | 5 MG
5Z-7-Oxozeaenol is a natural, fungal-derived small molecule that acts as a potent, irreversible, and selective inhibitor of TAK1 and VEGF-R2. It is used in biochemical and cellular research to probe TAK1- and VEGFR2-mediated signaling; reported IC50 values are 8 nM for TAK1 and 52 nM for VEGF-R2. The compound is supplied as a solid with high purity suitable for research applications.
- Potent, irreversible inhibition of TAK1 (IC50 = 8 nM).
- Selective activity against VEGF-R2 (IC50 = 52 nM).
- High purity suitable for biochemical and cellular assays.
- Solid form convenient for handling and storage.
- Useful for studying MAPKKK-mediated signaling pathways.
Cayman Chemical 5Z 2E-CU-3 25mg
A DGK-α inhibitor (IC50 = 0.6 µM for the porcine enzyme); selective for DGK-α over other type I DGKs, as well as type II, type III, type IV, and type V DGKs (IC50s = 7-36 µM); induces apoptosis in HeLa and HepG2 cells and enhances concanavalin A-induced increases in IL2 mRNA expression in Jurkat T cells at 5 µM
Abcam Epothilone D, Microtubule-stabilizing agent, 2MG
MW 491.7 Da. Microtubule-stabilizing agent. Epothilone A (ab143615) and B (ab141271) analog. Improves microtubule density and axonal integrity Shows antineoplastic and neuroprotective effects in vivo. Blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC Zearalenone
Zearalenone (F2 toxin RAL) is a non-steroidal estrogenic mycotoxin that acts by binding the estrogen receptor (ER)
Cayman Chemical 5Z 2E-CU-3 10mg
A DGK-α inhibitor (IC50 = 0.6 µM for the porcine enzyme); selective for DGK-α over other type I DGKs, as well as type II, type III, type IV, and type V DGKs (IC50s = 7-36 µM); induces apoptosis in HeLa and HepG2 cells and enhances concanavalin A-induced increases in IL2 mRNA expression in Jurkat T cells at 5 µM